Structural basis for the enhancement of virulence by viral spindles and their in vivo crystallization
Identifieur interne : 002797 ( Main/Exploration ); précédent : 002796; suivant : 002798Structural basis for the enhancement of virulence by viral spindles and their in vivo crystallization
Auteurs : Elaine Chiu [Nouvelle-Zélande] ; Marcel Hijnen [Australie] ; Richard D. Bunker [Nouvelle-Zélande] ; Marion Boudes [Australie] ; Chitra Rajendran [Suisse] ; Kaheina Aizel [Australie] ; Vincent Oliéric [Suisse] ; Clemens Schulze-Briese [Suisse] ; Wataru Mitsuhashi [Japon] ; Vivienne Young [Nouvelle-Zélande] ; Vernon K. Ward [Nouvelle-Zélande] ; Max Bergoin [France] ; Peter Metcalf [Nouvelle-Zélande] ; Fasséli Coulibaly [Australie]Source :
- Proceedings of the National Academy of Sciences of the United States of America [ 0027-8424 ] ; 2015.
Descripteurs français
- KwdFr :
- Animaux, Chitine (), Cristallisation, Cristallographie aux rayons X, Disulfures (), Domaine catalytique, Données de séquences moléculaires, Facteurs de virulence (), Facteurs de virulence (physiologie), Insectes, Insecticides (), Mixed function oxygenases (), Modèles moléculaires, Oxygène (), Oxygénases (), Polyosides, Poxviridae (métabolisme), Protéines virales (), Structure tertiaire des protéines, Structures macromoléculaires, Séquence d'acides aminés, Virulence, Virus ().
- MESH :
- métabolisme : Poxviridae.
- physiologie : Facteurs de virulence.
- Animaux, Chitine, Cristallisation, Cristallographie aux rayons X, Disulfures, Domaine catalytique, Données de séquences moléculaires, Facteurs de virulence, Insectes, Insecticides, Mixed function oxygenases, Modèles moléculaires, Oxygène, Oxygénases, Polyosides, Protéines virales, Structure tertiaire des protéines, Structures macromoléculaires, Séquence d'acides aminés, Virulence, Virus.
English descriptors
- KwdEn :
- Amino Acid Sequence, Animals, Catalytic Domain, Chitin (chemistry), Crystallization, Crystallography, X-Ray, Disulfides (chemistry), Insecticides (chemistry), Insects, Macromolecular Substances, Mixed Function Oxygenases (chemistry), Models, Molecular, Molecular Sequence Data, Oxygen (chemistry), Oxygenases (chemistry), Polysaccharides, Poxviridae (metabolism), Protein Structure, Tertiary, Viral Proteins (chemistry), Virulence, Virulence Factors (chemistry), Virulence Factors (physiology), Viruses (chemistry).
- MESH :
- chemical , chemistry : Chitin, Disulfides, Insecticides, Mixed Function Oxygenases, Oxygen, Oxygenases, Viral Proteins, Virulence Factors.
- chemistry : Viruses.
- metabolism : Poxviridae.
- chemical , physiology : Virulence Factors.
- Amino Acid Sequence, Animals, Catalytic Domain, Crystallization, Crystallography, X-Ray, Insects, Macromolecular Substances, Models, Molecular, Molecular Sequence Data, Polysaccharides, Protein Structure, Tertiary, Virulence.
Abstract
X-ray crystallography is a powerful approach for understanding the structure and function of biological macromolecules but is largely limited to molecules that form high-quality crystals in the laboratory. Here we present the structure of protein crystals that form naturally in virally infected insects and boost the insecticidal activity of oral pathogens. By proposing a mode of action for these virulence factors based on enzymes degrading chitin by oxidation, our findings may guide their use as synergetic additives to common bioinsecticides. They also reveal that these proteins assemble into ultra-stable crystals stabilized by a 3D network of covalent bonds, a unique strategy for achieving efficient protein crystallization in the complex environment of the cell.
Url:
DOI: 10.1073/pnas.1418798112
PubMed: 25787255
PubMed Central: 4386404
Affiliations:
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Le document en format XML
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<author><name sortKey="Schulze Briese, Clemens" sort="Schulze Briese, Clemens" uniqKey="Schulze Briese C" first="Clemens" last="Schulze-Briese">Clemens Schulze-Briese</name>
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, Dunedin,<country>9054, New Zealand</country>
</nlm:aff>
<country xml:lang="fr">Nouvelle-Zélande</country>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Amino Acid Sequence</term>
<term>Animals</term>
<term>Catalytic Domain</term>
<term>Chitin (chemistry)</term>
<term>Crystallization</term>
<term>Crystallography, X-Ray</term>
<term>Disulfides (chemistry)</term>
<term>Insecticides (chemistry)</term>
<term>Insects</term>
<term>Macromolecular Substances</term>
<term>Mixed Function Oxygenases (chemistry)</term>
<term>Models, Molecular</term>
<term>Molecular Sequence Data</term>
<term>Oxygen (chemistry)</term>
<term>Oxygenases (chemistry)</term>
<term>Polysaccharides</term>
<term>Poxviridae (metabolism)</term>
<term>Protein Structure, Tertiary</term>
<term>Viral Proteins (chemistry)</term>
<term>Virulence</term>
<term>Virulence Factors (chemistry)</term>
<term>Virulence Factors (physiology)</term>
<term>Viruses (chemistry)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term>
<term>Chitine ()</term>
<term>Cristallisation</term>
<term>Cristallographie aux rayons X</term>
<term>Disulfures ()</term>
<term>Domaine catalytique</term>
<term>Données de séquences moléculaires</term>
<term>Facteurs de virulence ()</term>
<term>Facteurs de virulence (physiologie)</term>
<term>Insectes</term>
<term>Insecticides ()</term>
<term>Mixed function oxygenases ()</term>
<term>Modèles moléculaires</term>
<term>Oxygène ()</term>
<term>Oxygénases ()</term>
<term>Polyosides</term>
<term>Poxviridae (métabolisme)</term>
<term>Protéines virales ()</term>
<term>Structure tertiaire des protéines</term>
<term>Structures macromoléculaires</term>
<term>Séquence d'acides aminés</term>
<term>Virulence</term>
<term>Virus ()</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Chitin</term>
<term>Disulfides</term>
<term>Insecticides</term>
<term>Mixed Function Oxygenases</term>
<term>Oxygen</term>
<term>Oxygenases</term>
<term>Viral Proteins</term>
<term>Virulence Factors</term>
</keywords>
<keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Viruses</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Poxviridae</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Poxviridae</term>
</keywords>
<keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Facteurs de virulence</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="physiology" xml:lang="en"><term>Virulence Factors</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Amino Acid Sequence</term>
<term>Animals</term>
<term>Catalytic Domain</term>
<term>Crystallization</term>
<term>Crystallography, X-Ray</term>
<term>Insects</term>
<term>Macromolecular Substances</term>
<term>Models, Molecular</term>
<term>Molecular Sequence Data</term>
<term>Polysaccharides</term>
<term>Protein Structure, Tertiary</term>
<term>Virulence</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Animaux</term>
<term>Chitine</term>
<term>Cristallisation</term>
<term>Cristallographie aux rayons X</term>
<term>Disulfures</term>
<term>Domaine catalytique</term>
<term>Données de séquences moléculaires</term>
<term>Facteurs de virulence</term>
<term>Insectes</term>
<term>Insecticides</term>
<term>Mixed function oxygenases</term>
<term>Modèles moléculaires</term>
<term>Oxygène</term>
<term>Oxygénases</term>
<term>Polyosides</term>
<term>Protéines virales</term>
<term>Structure tertiaire des protéines</term>
<term>Structures macromoléculaires</term>
<term>Séquence d'acides aminés</term>
<term>Virulence</term>
<term>Virus</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><title>Significance</title>
<p>X-ray crystallography is a powerful approach for understanding the structure and function of biological macromolecules but is largely limited to molecules that form high-quality crystals in the laboratory. Here we present the structure of protein crystals that form naturally in virally infected insects and boost the insecticidal activity of oral pathogens. By proposing a mode of action for these virulence factors based on enzymes degrading chitin by oxidation, our findings may guide their use as synergetic additives to common bioinsecticides. They also reveal that these proteins assemble into ultra-stable crystals stabilized by a 3D network of covalent bonds, a unique strategy for achieving efficient protein crystallization in the complex environment of the cell.</p>
</div>
</front>
</TEI>
<affiliations><list><country><li>Australie</li>
<li>France</li>
<li>Japon</li>
<li>Nouvelle-Zélande</li>
<li>Suisse</li>
</country>
</list>
<tree><country name="Nouvelle-Zélande"><noRegion><name sortKey="Chiu, Elaine" sort="Chiu, Elaine" uniqKey="Chiu E" first="Elaine" last="Chiu">Elaine Chiu</name>
</noRegion>
<name sortKey="Bunker, Richard D" sort="Bunker, Richard D" uniqKey="Bunker R" first="Richard D." last="Bunker">Richard D. Bunker</name>
<name sortKey="Metcalf, Peter" sort="Metcalf, Peter" uniqKey="Metcalf P" first="Peter" last="Metcalf">Peter Metcalf</name>
<name sortKey="Ward, Vernon K" sort="Ward, Vernon K" uniqKey="Ward V" first="Vernon K." last="Ward">Vernon K. Ward</name>
<name sortKey="Young, Vivienne" sort="Young, Vivienne" uniqKey="Young V" first="Vivienne" last="Young">Vivienne Young</name>
</country>
<country name="Australie"><noRegion><name sortKey="Hijnen, Marcel" sort="Hijnen, Marcel" uniqKey="Hijnen M" first="Marcel" last="Hijnen">Marcel Hijnen</name>
</noRegion>
<name sortKey="Aizel, Kaheina" sort="Aizel, Kaheina" uniqKey="Aizel K" first="Kaheina" last="Aizel">Kaheina Aizel</name>
<name sortKey="Boudes, Marion" sort="Boudes, Marion" uniqKey="Boudes M" first="Marion" last="Boudes">Marion Boudes</name>
<name sortKey="Coulibaly, Fasseli" sort="Coulibaly, Fasseli" uniqKey="Coulibaly F" first="Fasséli" last="Coulibaly">Fasséli Coulibaly</name>
</country>
<country name="Suisse"><noRegion><name sortKey="Rajendran, Chitra" sort="Rajendran, Chitra" uniqKey="Rajendran C" first="Chitra" last="Rajendran">Chitra Rajendran</name>
</noRegion>
<name sortKey="Olieric, Vincent" sort="Olieric, Vincent" uniqKey="Olieric V" first="Vincent" last="Oliéric">Vincent Oliéric</name>
<name sortKey="Schulze Briese, Clemens" sort="Schulze Briese, Clemens" uniqKey="Schulze Briese C" first="Clemens" last="Schulze-Briese">Clemens Schulze-Briese</name>
</country>
<country name="Japon"><noRegion><name sortKey="Mitsuhashi, Wataru" sort="Mitsuhashi, Wataru" uniqKey="Mitsuhashi W" first="Wataru" last="Mitsuhashi">Wataru Mitsuhashi</name>
</noRegion>
</country>
<country name="France"><noRegion><name sortKey="Bergoin, Max" sort="Bergoin, Max" uniqKey="Bergoin M" first="Max" last="Bergoin">Max Bergoin</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>
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